Sherlock Holmes is a consulting detective, who resides at 221b Baker Street.
He often works freelance taking cases that he finds interesting, and his investigations often lead him to working with Scotland Yard.
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As Holmes stares out of his window in boredom at September 6, 1894, having no worthy case to solve, he takes up Watson's suggestion of going to Barnes the Bookseller for books to entertain himself. While on the road, he soon finds one of his young friends selling newspapers and intrigued by the case of a Scandinavian royal in London, offers the young man and his friends coins if. In Barnes bookstore, while collecting legends about piracy and an illustrated volume of fish learns that a young Maori manservant, he swiftly deduces that Barnes is in love with Miss Flemming from the neglected flowers, proof of falling from a ladder and Watson's unnatural visit to the bookstore who works for Captain Stenwick, has mysteriously disappeared and advices the man to use chocolates instead and confirms Watson did not say anything about it but to no avail as Barnes later on blamed Watson for Holmes knowledge. On the way, he comes across Watson in Stenwick's house and learns that his servant was missing. With the information he acquires from Stenwick and Sergeant Ruffles about the young man and the fact that there are other similar cases and searching the servant's room, Holmes quickly deduces not only that the boy has been kidnapped, but also that two men – one significantly larger than the other – were responsible and confirms this to Stenwick and Ruffles and promises them he would do everything he could to find the truth.
Back in his home, after arguing with Watson regarding his treatment of Stenwick, he sends his friend to go to Barnes for books on the Maori and also contact the newsboy while he would conduct experiments from the clues he found. Using his chemicals and apparatus, Holmes discovers that the small lump of meatball that it contains a strong opium and morphine but cannot identify the other elements that compose it and from the piece of cloth he realizes that the ones responsible is very stealthy and athletic but is from India. With information from Watson, he deduces that the man responsible must be from the dock and goes to the Thames, where after thorough investigation, he and Watson learn that similar kidnappings have occured. Further investigation leads them to an abandoned subterranean temple, where they discover a bloody and tortured corpse upon a sacrificial altar. They also find opium with morphine which leads Holmes to deduce that it is being used as a kind of soporific to subdue victims, so that they can be abducted and trafficked out of the country.
After finding a crate labelled "Black Edelweiss Institute", Holmes recalls that the mountain flower Edelweiss (Leontopodium alpinum) is a national symbol of Switzerland. Upon arriving at the country and learning that the Black Edelweiss Institute is a Swiss mental asylum headed by a gentleman named Dr Gygax, Holmes and Watson hatch a plan to gain access and investigate. Knowing that he is about to willingly fall into the hands of criminals, Holmes sends Watson away from the asylum. This is primarily for his own safety, but also so that Holmes still has a connection with the outside world should things go awry once inside the Institute. Donning a costume and assuming a false identity, Holmes enters and is quickly incarcerated. After escaping from his cell, he finds further proof of Dr. Gygax's involvement in serious criminal activities. Not only has the doctor been performing dangerous experiments on helpless victims in the asylum, he is also part of a cult awaiting the arrival of the 'One'. Holmes unexpectedly discovers that his nemesis Moriarty is a patient and despite surviving the fall, he is but a weakened shadow of his former self and uses Moriarty as a distraction while Holmes extricates himself from the asylum.
Holmes and Watson head to New Orleans, as the city was mentioned in a telegram to Gygax. There, Holmes and Watson are taunted and harassed by the local sheriff who recognizes them as their passport has been stolen, effectively rendering their presence in New Orleans illegal, but soon discovers that they are aligned with the mysterious cult by their actions as they soon hear about a local man known as Mr. Arneson and his servant, a young lad named Davy, both of whom have been missing for days. Upon finding Davey, who is mute due to psychological trauma, Watson treats him and with help from Davy's sister, Davy writes on a chalkboard a series of numbers, which Watson copies down. Deducing Arneson is located in the swamp, Holmes and Watson purchase a boat using Arneson's money to travel there. Although they are too late to save the other sacrifices and are forced to in fact use them as bait for the crocodiles of the swamp, they manage to save Arneson, killing the crazed cult member that was about to sacrifice him, and retrieve an ancient book. Returning to New Orleans, Holmes and Watson deliver Arneson to Lucy and return to London. On the way, he tasks Watson with editing his monograph of the calculated trajectories of gull excretia while he tries to translate the book.
From Mycroft's letter revealing what he knows, Holmes deduces that the cult is motivated not by money but by a very dark and great purpose. With the book's language being archaic and only able to make out insanities and absurdities, Holmes has Barnes translate the book. Learning from the newsboy that many ships have been missing, Holmes and Watson go to the Thames to receive a chart of the sea of Scottland and manage to find a point named Ardnamurcham, which they identify from the bar keeper was a lighthouse that was right in the middle of the storm that takes down all the ships. With information from Barnes translation that the book tells of a terrifying sect devoted to strange entities, in particular the destructive and mythical sea god Leviathan, and that a priest would sacrifice persons representing the different nations to awake the demon so he would swallow the Earth.
Realizing the grim stakes of what could happen if the ritual was completed, Holmes and Watson quickly make haste to the Ardnamurcham lighthouse, where after a long journey from cavern undergrounds to the lighthouse, Holmes and Watson fight through the cultists guarding the top of the lighthouse and confront their leader Lord Rochester, whose fortune finances the sect. While Watson struggles to hold off the cultists, Holmes manages to emit the light needed to shine through the darkness of the night and storm and stop the 'summoning'. However, though they succeed in forcing the cultists to leave, Holmes fails to save Rochester, who jumps to his death into the raging sea below.
As Holmes contemplate on how sinister and dark Rochester and his cult and how genius they was despite their evil, he professes to Watson he fears of what the future may hold as he knows fully well the dangers of their society is far from being suppressed.
In July 1895, Holmes, in a progressively worse mood with each week due to the legendary French gentleman thief Arsène Lupin, who Holmes is rather interested in stopping, not arriving in Britain, swiftly gets his wish of getting into conflict with Lupin as Lupin sends a letter disguised as Arseno Lotinho threatens to steal five of England's most prized treasures to humble the "vanity" of the English, and leaves a riddle containing information on what his first crime will be. Holmes knows better than to dismiss the letter as just a joke and sends Watson to Barnes bookstore to research about a Spanish cape and one-eyed, one-armed man. With the information from Watson, Holmes determines that the theft will take place at the National Gallery, and upon arriving there deduce that the object will be The Fighting Temeraire, which is symbolic of Britain's victory over France and Spain in the Battle of Trafalgar. He alerts the Museum Director and Inspector Lestrade who has the Gallery guarded at every entrance. However, without Holmes himself present, Lupin easily defeats the guards and steals the painting. The next morning, Holmes and Watson investigate and Holmes deduces that Lupin disguised himself as a visiting French painter named Horace Velmont, and hid himself before Lestrade arrived. Lupin leaves behind a letter with a clue as to where he will strike next.
Holmes and Watson head to the Tower of London, were they believe Lupin will steal the ravens. They arrived too late, as the ravens are reported missing and replaced with other individual birds and a bat which have been let lose. They capture the animals and find pieces of paper attached to them. From the messages in the papers, Holmes deduces what Lupin will steal the Rosetta Stone at the British Museum and informs Lestrade and the Prime Minister. While Lestrade once again has the Museum guarded at every entrance, Lupin still manages to steal the stone right in front of them using ropes and leaves behind yet another letter.
Holmes determines that someone had unwittingly helped Lupin pass the security system and learning that Watson had befriended a journalist named Piers Urquhart Alenn who he helped into the museum to pay him back for favors, Holmes deduces, to his horror, that Lupin's next target will be Queen Victoria herself. At Buckingham Palace, Holmes and Watson find that the Prime Minister has had the place guarded heavily. Holmes learns that a French grandfather clock (which has a cupboard) was delivered to the queen's chamber and correctly deduces that Lupin made it to the queen and pursues Lupin in the secret corridor but only manages to find another letter which clues to his next and final crime.
The Prime Minister congratulates Holmes and Watson for their role in protecting the Queen and asks Watson to decipher Lupin's message. Watson initially deduces that the next crime will be at the Tower of London but the Prime Minister reminds him that Lupin already struck there. Watson then determines that the final target will be Big Ben. Holmes refuses to join Watson, the Prime Minister, Lestrade and much of Scotland Yard to wait for Lupin there and goes to the Tower of London, knowing Lupin will be there. He learns that Lupin's past four crimes were distractions from his real target, the Crown Jewels. Holmes sabotages Lupin's plan and confronts him. The two express their mutual admiration for each other. Lupin agrees to return the stolen items and Holmes lets him go, knowing they will not see each other again. Holmes later reveals everything to Watson and makes it clear he is not to write about this endeavor and hints that a woman is interested in him.
Sherlock Holmes is an extremely formidable individual whose capabilities has allowed him to prevent among the greatest and most darkest evil plots in history.
- Genius-level Intellect/Master Detective/Master Tactician: Regarded as the greatest detective in the world, Sherlock holds outstanding levels of sharp intellect and exceptionally fast and adaptive strategical abilities that has allowed him to successfully oppose and defeat many of the darkest and most cunning masterminds in secret.
- Scientific Knowledge: From his ability to successfully analyze the chemicals used by his enemies, Holmes has demonstrated indepth knowledge of science.
- Master Combatant: Although rarely shown in the gameverse, Holmes is still a capable fighter. This was shown when he easily defeated a tall and strong man using a chain, disarming him and holding him at sword point, in The Awakened and quickly defeated Peter Cairns in a boxing fight in Crimes and Punishment.
- Sherlock Holmes: The Mystery of the Mummy
- Sherlock Holmes: The Case of the Silver Earring
- Sherlock Holmes: The Awakened
- Sherlock Holmes versus Arsène Lupin
- Sherlock Holmes: The Mystery of the Persian Carpet
- Sherlock Holmes versus Jack the Ripper
- Sherlock Holmes and the Mystery of Osborne House
- The Testament of Sherlock Holmes
- Sherlock Holmes: Crimes & Punishments
- Sherlock Holmes: The Devil's Daughter